The Fanconi Anemia Core Complex Forms Four Complexes of Different Sizes in Different Subcellular Compartments
نویسندگان
چکیده
منابع مشابه
Towards a Molecular Understanding of the Fanconi Anemia Core Complex
Fanconi Anemia (FA) is a genetic disorder characterized by the inability of patient cells to repair DNA damage caused by interstrand crosslinking agents. There are currently 14 verified FA genes, where mutation of any single gene prevents repair of DNA interstrand crosslinks (ICLs). The accumulation of ICL damage results in genome instability and patients having a high predisposition to cancers...
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Signalling activity of β-catenin targeted to different subcellular compartments
Thilo HAGEN*1, Jaswinder K. SETHI†, Neale FOXWELL‡ and Antonio VIDAL-PUIG† *Wolfson Digestive Diseases Centre, University Hospital, Nottingham NG7 2UH, U.K., †Department of Clinical Biochemistry, University of Cambridge, Level 4, Box 232, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QR, U.K., and ‡The Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, U.K.
متن کاملFrequency of Hypothyroidism in Fanconi Anemia
Background: Fanconi anemia (FA) is a rare, autosomal recessive (AR) and multifactorial disorder. A high prevalence of FA observed in Iran is perhaps due to the high rate of consanguineous marriages. This study investigates the extent of short stature in patients with FA, the frequency of hypothyroidism in FA and the correlation between height and hypothyroidism. Methods: Eighteen patients with ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m400091200